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In a phase III clinical trial, 330 patients with progressive metastatic MTC were randomly assigned to the cabozantinib group ( n = 220) or the placebo group ( n = 110) ( Prognostic Effect of HGF/C-Met Signaling Pathway in Digestive System Cancer Previous clinical trials have indicated that that high expression of c-Met gene is involved in poor prognosis and high risk of many types of cancer

Recent studies have also reported that IF exerts a beneficial effect in different models of central nervous system (CNS) disorders or aged brain [12, 13]

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While this mechanism remains speculative, the underlying physiology of cryotherapy-induced blood flow changes supports the concept